Pyramidal cell regulation of interneuron survival sculpts cortical networks
نویسندگان
چکیده
منابع مشابه
Pyramidal Cell-Interneuron Circuit Architecture and Dynamics in Hippocampal Networks.
Excitatory control of inhibitory neurons is poorly understood due to the difficulty of studying synaptic connectivity in vivo. We inferred such connectivity through analysis of spike timing and validated this inference using juxtacellular and optogenetic control of presynaptic spikes in behaving mice. We observed that neighboring CA1 neurons had stronger connections and that superficial pyramid...
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Simon J. B. Butt,1 Inma Cobos,2 Jeffrey Golden,3 Nicoletta Kessaris,4 Vassilis Pachnis,5 and Stewart Anderson6 1Skirball Institute, New York University, New York, New York 10016, 2Department of Cell Biology, University of Barcelona, 08007 Barcelona, Spain, 3Department of Pathology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, 4Wolfson Institute for Biomedical Research,...
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High-frequency ripple oscillations, observed most prominently in the hippocampal CA1 pyramidal layer, are associated with memory consolidation. The cellular and network mechanisms underlying the generation, frequency control, and spatial coherence of the rhythm are poorly understood. Using multisite optogenetic manipulations in freely behaving rodents, we found that depolarization of a small gr...
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Cerebral cortical functions are conducted by two general classes of neurons: glutamatergic projection neurons and GABAergic interneurons. Distinct interneuron subtypes serve distinct roles in modulating cortical activity and can be differentially affected in cortical diseases, but little is known about the mechanisms for generating their diversity. Recent evidence suggests that many cortical in...
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ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-018-0139-6